Diseño y análisis en estudios post-genome-wide association (GWASs) (Osvaldo Espin-García)

Ciencias TVLun, octubre 28, 2019 3:02pmURL:
Embed:

Diseño y análisis en estudios post-genome-wide association (GWASs)

Plática dada por Osvaldo Espin-García (Dalla Lana School of Public Health, University of Toronto) en el Seminario de Estadística y Actuaría y de la Facultad de Ciencias de la UNAM, el jueves 24 de octubre del 2019 en el Auditorio Carlos Graef del Amoxcalli, en la Facultad de Ciencias de la UNAM

Video proporcionado por Ciencias TV

Video en Youtube
https://youtu.be/w4WDWvvjQdw

Foto de miniatura del video
https://photos.app.goo.gl/11DczM3HcxRRiD99A

Resumen:

Two-phase sampling design and analysis in post-genome-wide association studies (GWASs) can be a cost-effective strategy to infer association between sequencing data and a (quantitative) trait of interest. In phase 1, given a GWAS-identified genetic region, a subsample is selected using the outcome, Y, and an auxiliary covariate, Z, to inform the sampling. Phase 2 consists of collecting expensive targeted-sequence data, G, on the subsample alone, making G missing-by-design and reducing the sequencing costs. Lastly, inference on G is performed via semiparametric maximum likelihood by efficiently utilizing available data from phases 1 and 2. Two main approaches to select the phase 2 subsample are studied: heuristic and optimal designs.

Heuristic designs are practical and easy-to-implement sampling strategies that rely on alternative phase 2 sample allocations based on the phase 1 strata distribution. Four heuristic designs are examined: probability proportional to size, balanced, extreme, and a combination of extreme-balanced. Optimal designs, on the other hand, aim to select the phase 2 subsample under a budget constraint. Specifically, these strategies minimize features of the variance-covariance matrix based on predefined optimality criteria found in previous literature and common to experimental design. The proposed strategies implement such minimization via (1) Lagrange multipliers and (2) a genetic algorithm. The proposed methods are evaluated through comprehensive simulation studies. In addition, an illustration of these approaches using the Northern Finland Birth Cohort of 1966 is presented. We argue that two-phase studies can drastically reduce the costs of gathering sequencing data without substantial loss of power to detect genetic associations.

Agradecemos el apoyo de:

A Ricardo Martínez y Efrain Vega quienes grabaron y publicaron la plática

universo.math
http://universo.math.org.mx/
https://www.facebook.com/universo.math

Departamento de Matemáticas del CINVESTAV
http://www.math.cinvestav.mx/

Facultad de Ciencias de la UNAM
http://www.fciencias.unam.mx/
https://www.facebook.com/Facultad-de-Ciencias-214278861928417/?fref=t

La banda que coopero en la vaquita para reponer el equipo que nos robaron en noviembre del 2017
https://www.facebook.com/Ciencias.TV/videos/426024461479542/

Síguenos en:

https://docs.google.com/document/d/1zZjoiNfPfsPZN4LCrw3d6iYTSstfDC0zDgn1_vOvDJU/edit?usp=sharing

Página de Facebook de Ciencias TV:
https://www.facebook.com/Ciencias.TV

Página web:
http://cienciastv.org.mx

Ciencias TV – Matemáticas
https://www.facebook.com/Ciencias-TV-Matem%C3%A1ticas-106574140723552/

Ciencias TV – Física
https://www.facebook.com/Ciencias-TV-F%C3%ADsica-115341676509427/

Ciencias TV – Biología
https://www.facebook.com/Ciencias-TV-Biología-119061606164766/

Ciencias TV – Actuaría
https://www.facebook.com/Ciencias-TV-Actuaría-110097837065592

Ciencias TV – Química
https://www.facebook.com/Ciencias-TV-Química-100312398051685

Telegram:
t.me/cienciastv
@cienciastv

Twitter:
@Ciencias_TV

Instagram:
@ciencias.tv